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ISIC 19 : INVITED PLENARY LECTURES
TOPIC 1-Fundamentals of crystallization science
« Heterogeneous nucleation: The role of surface structure and chemistry »
In virtually all industrial processes , nucleation proceeds because of interactions with surfaces, impurities and various chemical species present in the solution. The role of surface structure and chemistry on nucleation will be discussed including experimental and simulation results.
Professor Allan Myerson, MIT (Massachusetts Institute of Technology) USA
Allan S. Myerson is Professor of the Practice in the Department of Chemical Engineering at the Massachusetts Institute of Technology.
The Myerson research group focuses on separation processes in the chemical and pharmaceutical industry with an emphasis on crystallization from solution. Professor Myerson is a co-PI in the Novartis-MIT Center for Continuous Manufacturing at MIT. He has published 5 books including the Handbook of Industrial Crystallization, 158 papers, and is the inventor on 32 U.S. patents. Professor Myerson has consulted for over 100 companies worldwide and was honored in 2008 with the American Chemical Society Award in Separations Science and Technology.
TOPIC 2-Characterization techniques of crystals and suspensions
« Self organized agregation . The numerics legacy »
Appearance of a particular solid phase from homogeneous medium has been studied from age to age. However, it is only recently that new developments could focus on a special key-point of the process, namely the very first times of the rare large microscopic density fluctuations (critical nuclei) able to give birth to structured phases. Such advancements were made possible through novel experimental (e.g. microfluidics), characterization (e.g. synchrotron), and numerical modeling (based on variants of Molecular Dynamics and Kinetic Monte-Carlo methods).
In this talk, we will review the state-of-the-art in various numerical approaches simulating the spontaneous appearance of aggregation and self-organization in unstable systems of molecules or suspensions of particles.
Dr Robert Botet , Laboratoire de Physique des solides, Paris, France
Dr Robert Botet is graduated from the high school Ecole Normale Supérieure de Cachan of Paris and has been working for the National Centre for Scientific Research (CNRS-France) since 1984, in the field of soft matter and physics-biology interface . His research is focused on modeling and numerical simulations of inhomogeneous matter, self-organized structures, structure and physical properties of nanoparticles aggregates, non-Gaussian fluctuations of the order parameter. His has published 118 papers in international journals with peer review, 2 books, 34 papers in published proceedings and 41 invited talks.
TOPIC 3-Process design, scale up, down stream processing,
“Population balance modeling coupled with computational fluid dynamics for crystallization: possibilities, limitations and open challenges”
This lecture describes the state of the art of population balance modeling coupled with computational fluid dynamics when employed to simulate crystallization and precipitation processes. The lecture will conclude with some guidelines designed to help future users of these computational tools to rationally select the best approach for different applications and the confidence with which predictions should be treated.
Professor Daniele Marchisio – Institute of Chemical Engineering – DISAT – Politecnico di Torino, Italy
Daniele L. Marchisio is an Associate Professor of Chemical Engineering in the Department of Applied Science and Technology of Politecnico di Torino (Italy). His research focuses on the development of multiscale computational models for polydisperse multiphase systems and reactors, coupling together (molecular dynamics), population balance models and computational fluid dynamics. He has contributed in developing quadrature-based moment methods (QMOM, DQMOM, CQMOM, etc.) which are now widely employed for the simulation of fluidized beds, bubble columns, gas-liquid stirred tanks, particle-laden flows and crystallization processes. He has co-authored one book for Cambridge University Press,
co-edited one for Springer Verlag and published more than 80 papers.
TOPIC 4-Product engineering
« Innovative methods for particle formation, formulation and characterization «
The lecture deals with hierarchical crystallization systems which follow unique self-organization pathways. At the level of semiconducting nanocrystals we follow their formation in great detail by unique optical techniques. Growth and ripening are modelled predictively allowing for rigorous mathematical optimization of particle size and optical properties by inverting the underlying population balances. As reactors we employ continuous microreactors and solvothermal reactors at elevated temperature and pressure. Finally we will address some of the key challenges in crystallization science and technology including aspects of the solid-liquid interphase, oriented attachment in combination with multidimensional characterization tools and novel modelling approaches of complex crystal systems.
Prof. Dr.-Ing. Wolfgang Peukert, University of Erlangen Germany
Full professor at the Friedrich-Alexander University Erlangen-Nuremberg, Germany
Institute of Particle Technology. His research interests are widespread in Particle Technology with emphasis on nanoparticle technology, product engineering and formulation technology, interface science and engineering.
Wolfgang Peukert has a track record of more than 200 publications in peer-reviewed scientific journals and books plus many papers in proceedings.
·- Ernest-Solvay Prize 2012
·- Leslie Ford Lecture, UK Particle Technology Forum 2008
·- Gottfried Wilhelm Leibniz Prize in 2005
·- Prize for the best PhD thesis related to environmental engineering, Karlsruhe 1990
TOPIC 5- Industrial challenges
« Continuous Crystallization in Pharmaceutical Manufacturing, an Industrial Perspective"
Dr Christopher Burcham , Eli Lilly and Company , Indianapolis USA
Christopher Burcham is an Engineering Research Advisor at Eli Lilly and Company and leads the Particle Design Laboratory. The group is responsible for the design and development of batch and continuous crystallization processes for all small molecule APIs currently under development.
Prior to leading the Particle Design Lab, he led the chemical process development for late stage molecules. He currently serves on a number of academic Industrial Advisory Boards and is very active in AIChE.
Christopher Burcham has a PhD from Princeton University and a BS from the University of Illinois, both in Chemical Engineering. His career started in Corporate R&D at The Dow Chemical Company transferring later to the Formulation Development group at Dow AgroSciences.